Etizolam (marketed under many brand names) is a thienodiazepine derivative which is a benzodiazepine analog.
The etizolam molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring and triazole ring has been fused, making the drug a thienotriazolodiazepine.
Although a thienodiazepine, etizolam is clinically regarded as a benzodiazepine because of its mode of action via the benzodiazepine receptor and directly targeting GABAA receptors.
It possesses anxiolytic, amnesic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.Etizolam is an anxiolytic found to have lower tolerance and dependence liability than benzodiazepines.
It was patented in 1972 and approved for medical use in 1983.
Tolerance, dependence and withdrawal
Abrupt or rapid discontinuation from etizolam, as with benzodiazepines, may result in the appearance of the benzodiazepine withdrawal syndrome, including rebound insomnia.
Neuroleptic malignant syndrome, a rare event in benzodiazepine withdrawal, has been documented in a case of abrupt withdrawal from etizolam.
This is particularly relevant given etizolam’s short half life relative to benzodiazepines such as diazepam resulting in a more rapid drug level decrease in blood plasma levels.
In a study that compared the effectiveness of etizolam, alprazolam, and bromazepam for the treatment of generalized anxiety disorder, all three drugs retained their effectiveness over 2 weeks,
but etizolam became more effective from 2 weeks to 4 weeks. Administering .5 mg etizolam twice daily did not induce cognitive deficits over 3 weeks when compared to placebo.
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It is a thienodiazepine derivative which is a benzodiazepine analog. Generally, it’s molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring.
Also, it has a fused triazole ring.Thus, etizolam is a thienotriazolodiazepine.
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It provides sedation, euphoria, and anxiety-reduction. Anxiety, depression, insomnia, and panic disorder are the medical uses in some regions.
Many people use this drug in non-medical settings.Most of the issues with the drug arise from excessive sedation, memory loss, and dis-inhibition. It becomes very dangerous at high does or when combined with other depressants.