What is JWH-019 ?
JWH-019 is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors.
It is the N-hexyl homolog of the more common synthetic cannabinoid compound
JWH-018. Unlike the butyl homolog JWH-073, which is several times weaker than
JWH-018, the hexyl homolog is only slightly less potent, although extending the
chain one carbon longer to the heptyl homolog JWH-020 results in dramatic loss of activity.
These results show that the optimum side chain length for CB1 binding in the
naphthoylindole series is the five-carbon pentyl chain, shorter than in the
classical cannabinoids where a seven-carbon heptyl chain produces the most potent compounds.
This difference is thought to reflect a slightly different binding conformation adopted by the naphthoylindole
compounds as compared to the classical cannabinoids, and may be useful in characterizing the active site of the CB1 and CB2 receptors.
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